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I was given Toradol for five days post operation (which is another wonderful medication) and Loratab to take along with it. I never had the need or desire to take the latter. But after Toradol was gone (I was able to stretch it over nine days) I still needed something else. I began to take Naproxen over-the counter strength and the pain and stiffness gradually came back. I had Cataflam, which after 2-3 dosages, controlled the discomfort that was building up.

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Pharmacoepidemiological data reveal an increased risk of arteriothrombotic events associated with diclofenac use, particularly at a high dose and during long-term treatment.

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Although serious GI tract ulcerations and bleeding can occur without warning symptoms, patients should be alert for the signs and symptoms of ulcerations and bleeding, and should ask for medical advice when observing any indicative sign or symptoms including epigastric pain, dyspepsia, melena, and hematemesis.

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Vicoprofen contains the same dose of ibuprofen as over- the- counter (OTC) NSAID, and is usually used for less than 10 days to treat pain.

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Several exploratory analyses were performed to delineate the relation between mean arterial pressure and the study findings.

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Relative benefit-risk comparing diclofenac to other traditional non-steroidal anti-inflammatory drugs and cyclooxygenase-2 inhibitors in patients with osteoarthritis or rheumatoid arthritis: a network meta-analysis.

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Diclofenac is a potent inhibitor of inducible cyclo-oxygenase (COX-2), resulting in a reduction of prostaglandin synthesis.

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Changes in key NSAID-related laboratory parameters are shown in the below Table 4 (“Analysis of Change in Laboratory Parameters”).

In rat studies with NSAIDs, as with other drugs known to inhibit prostaglandin synthesis, an increased incidence of dystocia, delayed parturition and decreased pup survival occurred.

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Diclofenac potassium tablets should be used in pregnancy only if the potential benefit justifies the potential risk to the fetus.

Some of the rarer types of side effects can include blood and bone marrow problems, blood in the urine, blurred vision, chest pain, colitis, constipation, convulsions, depression and difficulty sleeping.

Upper GI ulcers, gross bleeding, or perforation caused by NSAIDs occurred in approximately 1% of patients treated for 3 to 6 months, and in about 2% to 4% of patients treated for one year.

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In these patients, administration of an NSAID may cause a dose-dependent reduction in prostaglandin formation and, secondarily, in renal blood flow, which may precipitate overt renal decompensation.

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